Alleviation of Diabetic Dyslipidemia in Alloxan-Induced Diabetic Rats using Aqueous Seed Extract of Persea Americana

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Ukpabi, C
Okoro, O A
Ndulaka, J. C
Ndukwe, O. K
Chukwu M. N

Abstract

Diabetes Mellitus is accompanied by hypercholesterolemia, hyperlipidemia and hepatic steatosis apart from hyperglycemia. Alleviation of diabetic dyslipidemia in alloxan-induced diabetic rats using aqueous seed extract of Persea americana on induced Albino rats. A total of thirty Albino rats were divided into six groups of 5 rats: Group A: normal control, Group B: Negative control, Group C: Positive control 1, Group D: positive control 2, Group E: Test group 1, Group F: Test group 2. Intoxication of albino rats with alloxan monohydrate produced low high density lipoprotein (HDL), increased triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) after hyperglycemia. Results obtained from the diabetic study showed that plant extracts decreased blood glucose in a dose dependent fashion. The decrease was significant when compared to positive control 1. Similarly, treatment with the seed extracts normalized the lipoprotein abnormalities in dose dependent manner. The positive control 2 using atorvastatin was effective in TG and TC reduction while High dose aqueous seed extract of Peresa americana was effective in the normalization of LDL and HDL. Phytochemical composition of the aqueous seed extract gave reactions for alkaloids, flavonoids, tannins, saponins, phenols, steroids and cyanogenic glycosides. The findings may support acclaimed traditional use of Persea americana seed in controlling hyperglycemia in diabetes and its complications.

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